Multicenter Allergy Study

The German Multicenter Allergy Study (MAS-90) recruited 1,314 newborns in 1990 from six delivery wards in five cities and followed them prospectively. Among children with eczema in their first 2 years, 43.2% were in complete remission by age 3, 38.3% had intermittent disease and 18.7% had symptoms every year to age 7 (Illi 2004). Severity (aOR 5.86) and allergic sensitisation (aOR 2.76) were the main predictors of a worse course. Early eczema without early wheeze or sensitisation did not raise school-age asthma risk.

Connections

• Eczema Prognosis — key toddler remission data, source: Illi 2004
• Asthma — AD-plus-wheeze as a distinct phenotype, not a progression, source: Illi 2004
• Atopic March — severity strongest risk factor for poor prognosis, source: Medicina 2024