Atopic Dermatitis — source conflicts

Conflict: [Kim et al., JAAD 2016] says 80% of childhood AD has remitted by 8 years after diagnosis and <5% persists at 20 years. [Margolis et al., JAMA Dermatol 2014, PEER registry] says >80% of children aged 2–26 still had symptoms or used treatment, and only half had a 6-month clear spell by age 20. [Abuabara et al., Allergy 2018] found AD prevalence barely falls after age 12 (−1%, not significant). Unresolved — add to open_questions.

Conflict: [Classic atopic-march model, CHILD/PASTURE cohorts cited in Medicina 2024] says early AD leads to later asthma and rhinitis. [Belgrave 2014 latent-class analysis, cited in Medicina 2024] says only ~3.1–7% of children follow that trajectory, and co-occurrence ≠ causation. Unresolved — add to open_questions.

Conflict: [Abuabara et al., JACI 2019] adds that annual eczema prevalence shows no clear decline to midlife in British 1958/1970 cohorts, while [Illi et al., JACI 2004, MAS] shows 43% of early AD remitted by age 3. See prognosis-conflicts.md. Unresolved — add to open_questions.