Conflicts — contact-allergy (round 4)

Conflict: [Tam & Yu, Curr Allergy Asthma Rep, 2022] says patients with AD have “at least similar” ACD risk to non-AD patients, and that AD children in the US registry had lower rates of positive MCI/MI tests. [Bonamonte et al., Contact Dermatitis, 2022] found a higher patch-positive rate in AD children (36.9% vs 26.4%), with methylisothiazolinone and fragrance mixes more often positive in AD. Unresolved — add to open_questions. Note: Allergic Contact Dermatitis

Conflict: [Henley et al., NEJM, 2007] says repeated topical exposure to lavender and tea tree oils “probably caused” prepubertal gynaecomastia. [Braunstein et al., touchREVIEWS in Endocrinology, 2023] says the association is weak by Hill’s criteria and causation “has not been shown”; [Lawrence, Perfumer & Flavorist (fragrance-industry trade journal), 2008] likewise rejects causation. Unresolved — add to open_questions. Note: Essential Oils