Differentials — source conflicts

Conflict: [Alexopoulos et al., Pediatr Dermatol, 2014; Moises-Alfaro et al., Int J Dermatol, 2002] suggest infantile seborrhoeic dermatitis and AD may be clinical variants of the same disease. [Türe Avcı et al., Children, 2026; NHS cradle cap, n.d.; DermNet, 2017] treat ISD as a distinct, non-itchy, self-limiting condition with its own distribution. Unresolved — add to open_questions.

Conflict: [DermNet, 2021; Napolitano et al., 2022] say molluscum is more frequent, numerous or prolonged in children with AD, linked to barrier defects and FLG mutations. Napolitano also notes “there is not necessarily an association”, and [Türe Avcı et al., Children, 2026] says it “remains unclear whether molluscum-associated dermatitis occurs predominantly in individuals with underlying AD”. Unresolved — add to open_questions.

Conflict: [DermNet, Napkin dermatitis, 2017; NHS nappy rash, n.d.; AFP 2009] support a short course of mild hydrocortisone for inflamed nappy rash. [FDA OTC monograph M017] requires OTC hydrocortisone labels to state “do not use for the treatment of diaper rash”. Unresolved — add to open_questions.