Open questions — emollient-ingredients (round 3)

• Is there a regulator- or guideline-defined minimum age for urea emollients (e.g. BNF for Children, product SmPCs), and has any trial tested urea in under-5s?
• Does a ceramide cream improve adherence (and therefore outcomes) in toddlers with excoriated eczema, compared with a cheaper paraffin emollient? What is the cost difference per month at toddler doses?
• Do syndet or acidic (pH ~5) cleansers and emollients reduce flares or S. aureus colonisation in toddlers in a real RCT, beyond mouse and adult data?