Conflicts — oral-supplements-herbs (round 6)

Conflict: [Senapati et al., Indian J Dermatol Venereol Leprol, 2008, via Schäfer] says 500 mg EPO capsules beat 300 mg sunflower oil capsules over 5 months in a placebo-controlled RCT. [Bamford et al., Cochrane, 2013] says oral EPO and borage oil “are not effective treatments for eczema” across 27 RCTs. Unresolved — add to open_questions. Note: Evening Primrose Oil

Conflict: [Sheehan & Atherton, Br J Dermatol, 1992 (via Schäfer)] says a ten-herb decoction cut affected skin by 63% vs 6% on placebo in children with severe eczema. [Fung et al., Int J Dermatol, 1999; Hon et al., Br J Dermatol, 2007 (via Schäfer)] say Zemaphyte did no better than placebo, and that SCORAD fell at least as much on placebo as on CHM capsules in 85 children. Unresolved — add to open_questions. Note: Chinese Herbal Medicine

Conflict: [Cochrane (Gu et al.), 2013] says there is no conclusive evidence of benefit from oral or topical CHM. [National Eczema Association, 2025] says research has shown traditional Chinese medicine “helped ease certain symptoms of eczema in adults”, and lists it as a complementary option. Unresolved — add to open_questions. Note: Chinese Herbal Medicine

Conflict: [Camargo et al., J Allergy Clin Immunol, 2014] says 1,000 IU/day for one month significantly improved winter-related eczema in children (EASI −6.5 vs −3.3). [Lara-Corrales et al., J Cutan Med Surg, 2019] says 2,000 IU/day for three months in vitamin-D-insufficient children made no difference to severity (P = .7). Unresolved — add to open_questions. Note: Vitamin D

Conflict: [Nielsen et al., Nutrients, 2024; Hattangdi-Haridas et al., Nutrients, 2019] say vitamin D supplementation significantly reduces eczema severity in children and adults. [Bath-Hextall et al., Cochrane, 2012; AAD guideline 2014 via NCCIH] say there is no convincing, or inconsistent to no, evidence to recommend vitamin D for eczema. The newer meta-analyses post-date the Cochrane search (2010). Unresolved — add to open_questions. Note: Vitamin D

Conflict: [Niseteo et al., Nutrients, 2024] says an omega-3 + GLA + vitamin D supplement significantly reduced SCORAD and steroid use in 52 children over 4 months. [Bath-Hextall et al., Cochrane, 2012; Schäfer (largest well-documented fish oil trial)] say there is no convincing evidence of benefit from fish oil, and that the largest trial showed no difference from placebo. Unresolved — add to open_questions. Note: Fish Oil and Omega-3