Open questions — oral-supplements-herbs (round 6)

• Does vitamin D supplementation help toddlers aged 1–4 specifically (no trial has focused on this age), and does benefit depend on baseline deficiency or winter/latitude?
• Is there a subgroup of children who do not convert linoleic acid to GLA (e.g. those whose red-cell DGLA rises on supplementation) who benefit from EPO/borage oil, as the Henz 1999 subgroup and BMJ dissent suggest?
• Which ingredient (omega-3, blackcurrant GLA or vitamin D) drove the SCORAD fall in the Niseteo 2024 combination-product trial, and will it replicate in a larger, pre-registered trial?
• How often are Chinese herbal decoctions given to UK/South African toddlers screened for liver function, aristolochic-acid substitution or heavy metals?