Outcomes Comparison / Cost — source conflicts

Conflict: [GoodRx “How much is tacrolimus without insurance”, n.d.] gives average cash price of generic tacrolimus 0.03% 60 g as $133.12. [GoodRx tacrolimus price page, Sept 2025] gives the “average retail price” as $516.66. Unresolved — add to open_questions.

Conflict: [Emerson et al., Br J Dermatol 2001] found family costs ≈36% of total AD costs for UK preschoolers. [Filanovsky et al., J Pediatr 2016] found indirect costs dominated US families’ monthly spend ($199 of $274). Different settings and severity mixes. Unresolved — add to open_questions.

Conflict (carried over): [Evangelista 2014] coconut oil > mineral oil in children vs [Karagounis 2019; AAP] role “remains to be determined”. See herbal-home-remedies-conflicts.

Conflict (carried over): [Axon 2021; Cochrane Lax 2022] no harm from weekend TCS vs [Ahuja & Lio 2025] paediatric TSW cases at twice-weekly use. See proactive-therapy / topical-corticosteroids conflicts.