- Is skin bacteriotherapy (S. hominis A9, Roseomonas mucosa) safe and effective in children aged 1–4, and has any placebo-controlled paediatric trial reported? (Myles’ expanded 3–17 cohort results not retrieved.)
- Does SLS-containing toothpaste measurably worsen perioral or facial eczema in toddlers, and does switching to SLS-free toothpaste help? No trial located.
- How often is topical tacrolimus used off-label in UK/SA toddlers under 2 compared with licensed pimecrolimus, and does practice follow NICE’s specialist-initiation rule or PCDS’s GP-initiation advice?