Conflicts — probiotics (round 6)

Conflict: [Makrgeorgou et al., Cochrane, 2018] says currently available probiotics probably make little or no difference to eczema symptoms and that their use “is currently not evidence-based”. [NCCIH Clinical Digest, n.d. (cites 2021 RCT)] says “evidence suggests that probiotics may be effective for some, but not all, children”. It cites a 2021 RCT in children under 2 with cow’s-milk allergy. Unresolved — add to open_questions. (Carried over from herbal-home-remedies-conflicts.) Note: Probiotics

Conflict: [WAO GLAD-P, Fiocchi et al., 2015] suggests giving probiotics directly to high-risk infants (eczema RR 0.81), and [Pelucchi et al., 2012] found the effect “similar regardless of… the subject(s) receiving probiotics”. [Wei & Ding, J Int Med Res, 2026] found infant-only supplementation does not prevent AD (RR 0.94, 0.72–1.25), with earlier benefit driven by maternal-plus-infant regimens. Unresolved — add to open_questions. Note: Probiotics, World Allergy Organization

Conflict: [Kasrae et al., Int J Dermatol, 2015] says topical breast milk and hydrocortisone 1% “were found to have the same effects” on infant AD over 21 days. [Berents et al., BMC Dermatol, 2015] found “no effect” of fresh breast milk added to emollient versus emollient alone in children aged 4–32 months. Unresolved — add to open_questions. Note: Breast Milk

Conflict: [Kramer et al., PROBIT, JAMA, 2001; Flohr et al., JAMA Pediatr, 2017] say breastfeeding promotion reduced atopic eczema in infancy (OR 0.54) and flexural eczema at 16 years (OR 0.46). [Kramer & Kakuma, Cochrane, 2012] says exclusive breastfeeding for 6 vs 3–4 months shows no significant reduction in atopic eczema. Partly a difference in question (promotion vs duration), but unresolved — add to open_questions. Note: Breast Milk, PROBIT Trial